刘芳

加拿大健康科学院院士，教授，博士生导师。

刘芳教授从事精神疾病基础、临床与转化研究20余年，在精神疾病发病机制、生物标志物、药物开发及治疗研究取得了一系列国际领先的、突破性的原创性成果。在Nature、Cell、Neuron、Nature Medicine等期刊发表近百篇学术论文，H指数64；主持加拿大国家科研项目20余项，并获国际专利授权8项。曾荣获加拿大心血管基金会研究奖、美国精神分裂症和抑郁症研究联合会奖等多项荣誉。2019年当选加拿大健康科学院院士。2020年获聘多伦多大学Tapscott精神分裂症研究讲席教授。

1.专业研究方向：

① 精神疾病的分子机制和治疗

2. 近3年主要承担科研项目：

① Canadian Institute of Health Research (2018-2019): The role of FK506 binding protein 51in the regulation of glucocorticoid receptor signaling. PI

② Centre for Addiction and Mental Health Foundation Discovery Fund: Nanoparticle delivery of a therapeutic peptide for PTSD (2018-2020). PI

③ Miner's Lamp Innovation Fund (2019-2021): The DISC1-D2 protein complex as a biomarker for early detection of Schizophrenia. Co-PI

④ Canadian Institute of Health Research (2019-2024): The role of FK506 binding protein 51 in the regulation of glucocorticoid receptor signaling. PI

3. 近期代表文章(5篇) (通讯作者)

Li H, Su P, Lai TK, Jiang A, Liu J, Zhai D, Campbell CT, Lee FH, Yong W, Pasricha S, Li S, Wong AH, Ressler KJ, Liu F. The glucocorticoid receptor-FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder. J Clin Invest. 2020 Feb 3;130(2):877-889. doi: 10.1172/JCI130363. PMID: 31929189; PMCID: PMC6994126.

Li Y, Su P, Chen Y, Nie J, Yuan TF, Wong AH, Liu F. The Eph receptor A4 plays a role in demyelination and depression-related behavior. J Clin Invest. 2022 Mar 10:e152187. doi: 10.1172/JCI152187. Epub ahead of print. PMID: 35271507.

Su P, Lai TKY, Lee FHF, Abela AR, Fletcher PJ, Liu F. Disruption of SynGAP-dopamine D1 receptor complexes alters actin and microtubule dynamics and impairs GABAergic interneuron migration. Sci Signal. 2019 Aug 6;12(593):eaau9122. doi: 10.1126/scisignal.aau9122. PMID: 31387938.

Lee FHF, Zhang H, Jiang A, Zai CC, Liu F. Specific Alterations in Astrocyte Properties via the GluA2-GAPDH Complex Associated with Multiple Sclerosis. Sci Rep. 2018 Aug 27;8(1):12856. doi: 10.1038/s41598-018-31318-4. PMID: 30150703; PMCID: PMC6110783.